Theodoro Letícia Helena

Lecture title: Photodynamic effect of Butyl Toluidine Blue on the periodontal treatment

Periodontitis is a chronic multifactorial inflammatory disease associated with dysbiotic plaque and is characterized by progressive destruction of the tooth‐supporting apparatus. Non-surgical treatment of scaling and root planing (SRP)  is the recommended initial therapy. Despite satisfactory results, limitations of this mechanical therapy and the better understanding of periodontal disease have led to the development of adjuvant methods for SRP. Therefore, the search for adjuvant therapies that do not cause bacterial resistance to replace antibiotics in the treatment of periodontitis is needed. Antimicrobial photodynamic therapy (aPDT) has been studied as a promising adjuvant therapy for controlling bacterial infections. The criteria for successful aPDT require the consideration of light delivery, oxygen availability and photosensitizer (PS) administration. Due to the variety of PS and different irradiation protocols used in periodontal treatment, comparative studies are needed to clarify and encourage the standardization of these clinical and physical parameters, thus reducing the discrepancy in the results of aPDT in the treatment of periodontitis. Butyl toluidine blue (BuTB) was developed by physicochemical modifications of the molecular structure of the established phenothiazine dye toluidine blue O. The current presentation will demonstrate the in vivo (animals and humans) effects of the PS BuTB on the treatment of periodontitis.