- Education: Biology graduate from the Faculty of Sciences at the University of Genoa, Italy, and holds a Ph.D in Environmental Sciences from the same institution and University.
- Specialization: Completed his specialization in the Methodology of Bioelectromagnetic Experimental Investigations at the European BioElectromagnetics Association (EBEA) and the International School of Bioelectromagnetism “Alessandro Chiabrera” at the Ettore Majorana Center in Erice, Italy.
- Teaching Experience: Previously held positions as an Adjunct Professor at the Department of Surgical Sciences and Integrated Diagnostic (DISC) at the University of Genoa, Italy, and at the Department of Orthopaedic Dentistry at the First Moscow State Medical University (Sechenov University) in the Russian Federation.
- Current Role: Currently serving as a Professor at the School of Mathematics, Physics and Natural Sciences, Department of Earth, Environmental and Life Sciences, University of Genoa, Italy.
- Editorial Experience: He serves as an Associate Editor at Frontiers Publisher for Frontiers in Medicine (Translational Medicine) and Frontiers in Photonics.
Steering Multipotent Mesenchymal Cells towards an Anti-inflammatory and Osteogenic Bias through Photobiomodulation Therapy: Achieving Dual Benefits
The multipurpose features and clinical applications of bone marrow-derived multipotent mesenchymal cells (MSCs) have captured scientific interest. MSCs not only exert bone-building and niche anabolic tasks but also possess the ability to quench inflammation and restore inflamed tissues, extending their range of activities to conditions such as neurodegenerative diseases, immune disorders, and various forms of osteopenia. Manipulating MSCs to become an effective therapeutic tool has become necessary. Photobiomodulation therapy (PBM-t) can be used to render MSCs an extraordinary anti-inflammatory and osteogenic instrument by improving their plasticity and secretome. Laser pre-conditioning and PBM-t protocols improve the anti-inflammatory and osteogenic capacity of MSCs, prompt these multipotent stem cells towards a predefined lineage commitment and secretome, and improve their viability and proliferation. Consistent therapeutic approaches are essential in considering the physical properties of light, the reliability of laser parameters, and individual patient needs. The field needs to shift from pre-clinical evidence to reliable therapies, which involve determining the effectiveness, safety, posology, and clinical utility of PBM-t protocols. Our research team suggests that delivering 808-nm infrared light at 1W and 60 J/cm2 (60 sec) through a flat-top handpiece (1 cm2) is a promising strategy for improving MSC differentiation, secretion, and anti-inflammatory capabilities, establishing the clinical utility of this approach.